Corticostriatal Plasticity and Behavioral Flexibility in Compulsivity: Convergent Influence of Physical Activity and Serotonergic Signaling

Authors

  • Nada Alaa Ahmed Moustafa, Akmal Ahmed Hassan Diab, Maha Abdelhamid Fathy, Abeer Abdelmonem Saied Ibrahim

Keywords:

corticostriatal circuitry, serotonin, exercise, behavioral flexibility.

Abstract

Background: Compulsivity can be viewed physiologically as a failure to appropriately regulate, interrupt, or updateactions once they become maladaptive. Contemporary models of obsessive-compulsive disorder increasingly emphasize dysfunction within cortico-striato-thalamo-cortical networks together with altered interactions among serotonin,dopamine, glutamate, and plasticity-related signaling systems

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References

Goodman WK, Grice DE, Lapidus KAB, Coffey BJ. Obsessive-compulsive disorder. Psychiatr Clin North Am. 2014;37(3):257-267.

doi:10.1016/j.psc.2014.06.004.

Burguière E, Monteiro P, Mallet L, Feng G, Graybiel AM. Striatal circuits, habits, and implications for obsessive-compulsive disorder. Curr Opin

Neurobiol. 2015;30:59-65.

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Published

2024-03-20

How to Cite

Nada Alaa Ahmed Moustafa, Akmal Ahmed Hassan Diab, Maha Abdelhamid Fathy, Abeer Abdelmonem Saied Ibrahim. (2024). Corticostriatal Plasticity and Behavioral Flexibility in Compulsivity: Convergent Influence of Physical Activity and Serotonergic Signaling . Pegem Journal of Education and Instruction, 14(3), 1278–1285. Retrieved from https://www.pegegog.net/index.php/pegegog/article/view/5325

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

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