The Impact of Viral, Molecular, and Immunological Factors on Hepatocellular Carcinoma Recurrence After Curative Resection

Authors

  • Ahmed Mohamed Nasr El-Din Mohamed Bekhit , Soha Esmat Khorshid , Wael Salah El-Din Mansy , Ahmed Lotfy Sharaf , Nabila Hassan Ahmed

Keywords:

Hepatocellular carcinoma; Curative resection; Hepatitis B virus; Tumor microenvironment; Biomarkers

Abstract

Background: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a leading causeof cancer-related mortality worldwide. Curative liver resection offers an effective treatment option for patients withpreserved liver function and resectable tumors; however, postoperative recurrence remains the principal challenge, occurring in up to 70% of patients within five years. Tumor recurrence results from a complex interplay between residualmicroscopic disease, de novo hepatocarcinogenesis,

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References

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660

Imamura H, Matsuyama Y, Tanaka E, et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol. 2003;38(2):200-207. doi:10.1016/S0168-8278(02)00360-4

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Published

2024-03-15

How to Cite

Ahmed Mohamed Nasr El-Din Mohamed Bekhit , Soha Esmat Khorshid , Wael Salah El-Din Mansy , Ahmed Lotfy Sharaf , Nabila Hassan Ahmed. (2024). The Impact of Viral, Molecular, and Immunological Factors on Hepatocellular Carcinoma Recurrence After Curative Resection. Pegem Journal of Education and Instruction, 14(3), 1263–1277. Retrieved from https://www.pegegog.net/index.php/pegegog/article/view/5321

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

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