Artificial Sweeteners and Hippocampal Neuronal Activation: Molecular Insights from c-Fos Signaling and Oxidative Stress Pathways

Authors

  • Amal Al-Shahat Ibrahim, Abdulrahman Alshahat Mohamed Khalil, Dalia Ali Hassan Aiad, Noura Mohamed Qenawy Ahmed

Keywords:

Artificial sweeteners; Hippocampus; c-Fos; Immediate early genes; Neuronal activation; Oxidative stress; Neuroplasticity; Aspartame; Non-nutritive sweeteners; Memory circuits; Synaptic signaling; Hippocampal neurons

Abstract

Background: Artificial sweeteners are widely used as non-caloric substitutes for dietary sugars and are increasinglyincorporated into beverages, processed foods, and pharmaceutical preparations. While these compounds are generally regarded as safe within approved intake levels, growing experimental evidence suggests that certain artificial sweetenersmay influence neural activity within brain regions

Downloads

Download data is not yet available.

References

Sylvetsky AC, Rother KI. Trends in the consumption of low-calorie sweeteners. Physiol Behav. 2016;164:446-450.

Magnuson BA, Carakostas MC, Moore NH, Poulos SP, Renwick AG. Biological fate of low-calorie sweeteners. Nutr Rev. 2016;74(11):670-689.

Downloads

Published

2024-03-20

How to Cite

Amal Al-Shahat Ibrahim, Abdulrahman Alshahat Mohamed Khalil, Dalia Ali Hassan Aiad, Noura Mohamed Qenawy Ahmed. (2024). Artificial Sweeteners and Hippocampal Neuronal Activation: Molecular Insights from c-Fos Signaling and Oxidative Stress Pathways. Pegem Journal of Education and Instruction, 14(3), 969–980. Retrieved from https://www.pegegog.net/index.php/pegegog/article/view/4943

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

NonCommercial — You may not use the material for commercial purposes.

No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.